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課程名稱 |
生物統計與流行病學
Biostatistics and Epidemiology |
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開課學期 |
101-2 |
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授課對象 |
醫學院 法醫學研究所 |
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授課教師 |
陳秀熙 |
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課號 |
PH2021 |
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課程識別碼 |
801 21410 |
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班次 |
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學分 |
4 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期五5,6,7,8(12:20~16:20) |
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上課地點 |
公衛101 |
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備註 |
上課地點:公衛101教室與江怡德、李宜家、邱瀚模、潘信良、陳祈玲、方啟泰、李永凌、嚴明芳、林先和合開
總人數上限：240人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1012statistics_epi |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
本課程包含生物統計學與流行病學兩大部分，將淺入深出地自資料初探開始，以科學原則探討統計分佈及基本原理（假設檢定及估計）及其應用於流行病學測量指標，再以統計推理方式探討流行病學因果關係推論，之後將探討統計方法與實證醫學研究設計，並應用於實驗性流行病學，再以類實驗研究設計及相關統計方法應用於兩個流行病學常用之世代追蹤研究、病例對照研究等。最後再將多元迴歸方程式模式應用於臨床流行病學、傳染病流行病學、遺傳流行病學等主題。
This course is divided into two parts, biostatistics and epidemiology. This course begins with the basic theory of statistics (including statistical distribution, hypothesis testing and estimation) and their links with basic measurements of descriptive epidemiology and causal relationships implicated in analytic epidemiology. We then unify basic statistical methods with experimental epidemiological method to reach the principles of evidence-based medicine (EBM). We also impart quasi-experimental design with two major epidemiological designs, prospective cohort study and case-control study. Finally, we applied our statistical regression model to different fields of epidemiology, including clinical epidemiology, infectious epidemiology and genetic epidemiology. |
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課程目標 |
本課程主要是啟發及引導醫學及牙醫系學生對於生物統計與流行病學在醫學及牙醫（特別是實證醫學）扮演之角色，並從科學角度及觀點探討如何結合統計原理與流行病學方法，針對醫學及牙醫所提出之研究假說及研究設計下產生之實證資料進行分析，並激發同學進一步學習的興趣，並具備下列知能 (competencies)：
1. 研究問題提出合適之研究假說
2. 以流行病學角度提出合適的研究設計
3. 以統計思維描述資料型態並進行檢定假說及估計
The objective of this course is to inspire and to guide medical and dental students to enrich the knowledge and theory of biostatistics and epidemiology. Specifically, we are tempted to impart students to use the concepts of biostatistics and epidemiology to answer research hypothesis with good epidemiological study designs and statistical analysis in order to provide the following competences:
1. To formulate research hypothesis on specific scientific questions
2. To propose a good epidemiological design
To explore the empirical data with statistical distribution and frame statistical questions with the concept of statistical inference |
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課程要求 |
本課程並未指定單一教科書，但列有參考書目。不印講義，每周上課講義皆置於Ceiba課程網站上供同學自行下載。隨課程進行，有對應之作業會於課堂公布之。每學期共舉行兩次考試，期中與期末考。
The textbooks and reference books are listed below. The teaching material is available from CEIBA website. The students are expected to listen to the lecture and practice. Evaluation includes mid-term, final examination and regular exercise.
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Beth Dawson, Robert G. Trapp Basic & clinical biostatistics New York :
Lange Medical Books-McGraw-Hill, Medical Pub. Division, c2004
2. Robert C. Elston, William D. Johnson Basic biostatistics for geneticists
and epidemiologists : a practical approach Chichester, U.K. : John Wiley & Sons,
2008
3. Bryan Kestenbaum Epidemiology and biostatistics : an introduction to
clinical research New York 2009
4. Breslow NE, Day NE. Statistical methods in cancer research. Volume I -
the analysis of case-control studies IARC Sci Publ, 1980; (32):5-338.
5. William M. Bolstad Introduction to Bayesian statistics Hoboken, N.J. :
John Wiley, c2007 |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
2/22 |
統計分佈與描述流行病學基本測量 (1)
Statistical Distribution and the Principles of Measurement of Descriptive Epidemiology (1) |
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第2週 |
3/01 |
統計分佈與描述流行病學基本測量 (2)
Statistical Distribution and the Principles of Measurement of Descriptive Epidemiology (2)
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第3週 |
3/08 |
統計科學推理與分析流行病學因果關係測量 (1)
Reasoning with Statistical Science and Causal Inference in Analytic Epidemiology
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第4週 |
3/15 |
統計科學推理與分析流行病學因果關係測量 (2)
Reasoning with Statistical Science and Causal Inference in Analytic Epidemiology
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第5週 |
3/22 |
統計檢定力與流行病學樣本數估計
Statistical Power Function and Sample Size Determination in Epidemiology
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第6週 |
3/29 |
辛普森矛盾之統計觀與流行病學干擾因子與交互作用
Statistical Aspect of Simpson’s Paradox and Confounding and Interaction in Epidemiology
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第7週 |
4/05 |
溫書假 |
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第8週 |
4/12 |
實證醫學科學統計與流行病學實驗性研究 (1)
Statistical Evidence-based Medicine (EBM)–Experimental Design in Epidemiology (1)
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第9週 |
4/19 |
期中考/ Mid Exam |
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第10週 |
4/26 |
實證醫學科學統計與流行病學實驗性研究 (2)
Statistical Evidence-based Medicine (EBM)–Experimental Design in Epidemiology (2)
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第11週 |
5/03 |
統計於世代追蹤研究之應用 (1)
Statistical method for Epidemiological Cohort Study (1)
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第12週 |
5/10 |
統計於世代追蹤研究之應用 (2)
Statistical method for Epidemiological Cohort Study (2)
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第13週 |
5/17 |
統計於病例對照研究之應用(1)
Statistical method for Epidemiological Case-Control Study (1)
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第14週 |
5/24 |
統計於病例對照研究之應用(2)
Statistical method for Epidemiological Case-Control Study (2)
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第15週 |
5/31 |
臨床流行病學與迴歸模式之應用
Application of Regression Model to Clinical Epidemiology
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第16週 |
6/07 |
傳染病流行病學與迴歸模式之應用
Application of Regression Model to Infectious Disease Epidemiology
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第17週 |
6/14 |
遺傳流行病學與迴歸模式之應用
Application of Regression Model to Genetic Epidemiology
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第18週 |
6/21 |
期末考/Final Exam |
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